Douglas J Perkins Selected Research

hemozoin

3/2022	Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes.
7/2019	Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling.
10/2016	Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB activation.
8/2012	Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.
7/2009	Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism.
1/2007	Role of monocyte-acquired hemozoin in suppression of macrophage migration inhibitory factor in children with severe malarial anemia.
9/2006	Acquisition of hemozoin by monocytes down-regulates interleukin-12 p40 (IL-12p40) transcripts and circulating IL-12p70 through an IL-10-dependent mechanism: in vivo and in vitro findings in severe malarial anemia.
5/2006	Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia.
12/2004	Hemozoin differentially regulates proinflammatory cytokine production in human immunodeficiency virus-seropositive and -seronegative women with placental malaria.
8/2004	Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells.

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Douglas J Perkins Research Topics

Disease

33	Malaria 06/2022 - 01/2002
29	Anemia 01/2022 - 08/2004
14	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2019 - 01/2004
11	Parasitemia 01/2016 - 11/2003
9	Infections 03/2022 - 11/2003
6	COVID-19 01/2022 - 01/2020
5	Bipolar Disorder (Manic Depressive Psychosis) 04/2021 - 01/2016
5	Bacteremia 01/2019 - 01/2007
5	Acute malaria 07/2012 - 07/2005
4	Coinfection 01/2016 - 01/2002
3	Cerebral Malaria 07/2013 - 05/2005
3	Communicable Diseases (Infectious Diseases) 03/2013 - 09/2006
2	Sickle Cell Trait 12/2011 - 11/2011
2	Glucosephosphate Dehydrogenase Deficiency 12/2011 - 11/2011
2	Parasitic Diseases (Parasitic Disease) 06/2007 - 05/2006
2	HIV Infections (HIV Infection) 12/2004 - 01/2002
1	Leishmaniasis 01/2021
1	Child Nutrition Disorders 01/2021
1	Diabetes Mellitus 01/2020
1	Psychotic Disorders (Schizoaffective Disorder) 12/2018
1	Hypothyroidism 01/2016
1	Cystic Fibrosis (Mucoviscidosis) 12/2013
1	Acute Disease 08/2011

Drug/Important Bio-Agent (IBA)

15	Hemoglobins (Hemoglobin)IBA 01/2021 - 05/2005
12	hemozoinIBA 03/2022 - 11/2003
10	CytokinesIBA 01/2017 - 01/2002
7	Interleukin-12 (IL 12)IBA 01/2016 - 01/2002
6	Interleukin-10 (Interleukin 10)IBA 01/2016 - 01/2004
5	InterleukinsIBA 03/2013 - 01/2002
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2008 - 05/2005
4	Pharmaceutical PreparationsIBA 04/2021 - 01/2016
4	Antipsychotic Agents (Antipsychotics)IBA 01/2020 - 01/2016
4	Proteins (Proteins, Gene)FDA Link 07/2019 - 01/2002
4	Dinoprostone (PGE2)FDA Link 07/2013 - 01/2004
4	Macrophage Migration-Inhibitory FactorsIBA 08/2009 - 05/2006
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2020 - 01/2004
3	ProstaglandinsIBA 01/2020 - 01/2004
3	LithiumIBA 01/2019 - 01/2016
3	Anticonvulsants (Antiepileptic Drugs)IBA 01/2019 - 01/2016
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 11/2011
3	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 07/2013 - 05/2005
3	Interleukin-13IBA 03/2013 - 11/2011
3	Prostaglandins EIBA 08/2012 - 11/2003
3	Immunoglobulin G (IgG)IBA 03/2012 - 04/2006
3	Chemokine CCL5IBA 07/2009 - 07/2005
3	ChemokinesIBA 10/2006 - 01/2002
2	Drug CombinationsIBA 01/2020 - 01/2019
2	Interleukin-7 (Interleukin 7)IBA 01/2019 - 01/2016
2	Antidepressive Agents (Antidepressants)IBA 01/2019 - 12/2018
2	Interleukin-17 (Interleukin 17)IBA 01/2017 - 01/2016
2	CreatinineIBA 07/2013 - 05/2005
2	InterferonsIBA 08/2012 - 01/2002
2	AntibodiesIBA 03/2012 - 04/2006
2	Interleukin-18 (Interleukin 18)IBA 12/2011 - 01/2002
2	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 12/2011 - 11/2011
2	Interleukin-12 Subunit p40IBA 02/2008 - 09/2006
1	insulin receptor-related receptor (IRR)IBA 06/2022
1	Complement C3 (C3 Complement)IBA 01/2022
1	Protein Disulfide-IsomerasesIBA 01/2021
1	remdesivirIBA 12/2020
1	Antiviral Agents (Antivirals)IBA 12/2020
1	Clopenthixol (Zuclopenthixol)IBA 12/2020
1	Amodiaquine (Camoquin)FDA Link 12/2020
1	Nebivolol FDA Link 12/2020
1	favipiravirIBA 12/2020
1	artemisinin (artemisinine)IBA 10/2020
1	Neutralizing AntibodiesIBA 10/2020
1	Investigational DrugsIBA 10/2020
1	2-thioxo-4-thiazolidinecarboxylic acid (TTCA)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	tyrosyl-tyrosyl-glutamyl-glutamic acidIBA 01/2020
1	Complement C1q (C1q Complement)IBA 07/2019
1	lipoteichoic acidIBA 01/2019
1	LipopolysaccharidesIBA 01/2019
1	Glutamine (L-Glutamine)FDA Link 10/2016
1	NF-kappa B (NF-kB)IBA 10/2016
1	Interleukin-5 (Interleukin 5)IBA 01/2016
1	Interleukin-15 (Interleukin 15)IBA 01/2016
1	Interleukin-4 (Interleukin 4)IBA 01/2016
1	Oxcarbazepine (Trileptal)FDA LinkGeneric 01/2016
1	Inflammation MediatorsIBA 01/2016
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2016
1	piperaquineIBA 01/2014
1	TabletsIBA 01/2014
1	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2014
1	artenimol (dihydroartemisinin)IBA 01/2014
1	Interleukin-8 (Interleukin 8)IBA 12/2013
1	Antimalarials (Antimalarial Agents)IBA 03/2012
1	3' Untranslated Regions (3' UTR)IBA 08/2011
1	LipidsIBA 01/2011
1	Pregnenolone Carbonitrile (PCN)IBA 04/2010
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2010
1	Interleukin-23 (Interleukin 23)IBA 02/2008

Therapy/Procedure

5	Therapeutics 12/2020 - 01/2016
4	Drug Therapy (Chemotherapy) 04/2021 - 12/2018
3	N95 Respirators 01/2021 - 01/2020
2	Polypharmacy 01/2020 - 01/2019
1	Length of Stay 01/2022
1	Art Therapy 01/2021
1	Aftercare (After-Treatment) 12/2018